My favorite .45 Colt load is a 230 grain cast bullet at just under 1100 fps. I shoot 255's at 1300+ every once in a while just for fun, but the fun wears off after about a dozen shots. Maybe I'm a wimp. Or maybe I just need to take the purdy checkered grips off my gun and put the original smooth walnut grips back.
A 250-ish grain cast bullet atop a full case of blackpowder is no slouch either.
"The only way to stop a bad guy with a gun is with a good guy with a gun"