It's very easy to accomplish hard hitting
Any heavier than standard bullet at 900-1000 fps will whack the bejeesus out of just about anything on the other end. A great bullet is the 270 grain SAA from RCBS. It drops a bit heavier than stated weight and will do it all without excess powder, recoil or wear on your gun.
With a better bullet design even standard weights and velocities will hit harder than most handgun bullets.