When I was six, my dad took me hunting for the first time after an hour or more of how to use the shotgun, and gun safety. That was the only time I had to carry a firearm with an empty chamber, that was 50 years ago.
Personally, having a firearm, other than a revolver, without a manual safety would never be a consideration for me, just too ingrained in my weapon craft that it is a must have.
The safety is being flipped off the moment the pistol clears the holster with trigger finger still straight across the guard (another safety).
Never had to draw in a crisis, but have practiced it hundreds of times empty, and live fire.
Please find a mental and physical method that allows you to carry in the utmost ready capability. Having to operate the slide and hope that everything goes well in what will seem like an eternity just doesn't seem logical?