My wife had a hard time racking the slide on my Ruger P95. It was a simple fix due to it being a technique issue rather than a lack of strength.
If someone tries to just pull the slide back, it's going to be harder on them to process it. The trick is to push the hand holding the grip forward while pulling the hand on the slide back.
I'd venture most semi-automatic pistols fall into this category, and I'd honestly rather have my wife carrying a semi-automatic for the sole purpose of having more rounds at her disposal as well as sharing the same caliber rounds as I use for practicality.