I prefer the Ruger MK for 2 reasons.
1. It is easy to mount a red dot like a fastfire. Burris makes a conformal mount that does not require the rail to be installed. It makes it supremely accurate. And the red dot clears a suppressor.
2. Buy a Cliploader for $25, and you can load the mags in 2 seconds without ending up with aching fingers. Just dump a box of ammo in and push in the mag, amazing. (works with the 22/45 as well, but requires a minor screw adjustment.
They seem to last forever...