My wife and I have kids, so no 'nightstand' firearms for us. GunVaults are under the bed - Sig P220 and P239 (9mm) full magazines + 1 in the chamber. (his and hers... cute, eh?) Our house is situated in such a way that as soon as an alarm is tripped we can access the pistol and be in the hallway in about ten seconds. That is way faster than anyone can get in the door (or window) and up the steps.
My other firearms are all in a locked room in safes. One AR, one AK-47 and a Saiga 12 are quickly accessible with loaded magazines next to each (again, locked in safe).