Another vote for the Speer 135gr short barrel load. My wife's 2 3/4" Ruger Security Six is loaded with the Speer ammo. It's very very controllable load in 32oz revolver.
My 4" S&W M13 that sits on my nightstand is loaded with the old standby FBI load (remington 158gr LSWCHP +P .38). I want an effective load, but a fire breathing 125gr .357 is overkill indoors.