Howabout a lever rifle in 32-20? With a headshot it would take a small 100# deer readily. With a solid bullet, cast or otherwise, would take a squirrel.
Else a TC contender in a holster in a scoped rimfire chambering, and a 243 or 30-30 in a short rifle.
Makes you wonder sometimes, there are so many cartridges available these days that no single cartridge seems to meet all needs.