I think were I in a situation where something big and mean was trying to grind me into an indecipherable paste, I'd want at least a .500 Nitro.
With an underbarrel Phoenix missile.
The British considered rounds like the 9.3 and the .375 to be medium bores, suitable for hunting most game, including dangerous game, under optimal conditions.
But, when things went badly, as they sometimes did, the British professional hunter liked to have a native gun bearer whose sole job it was to walk a pace ahead and to the right of the the Bwana with a big ass double rifle on his left shoulder, muzzles forward.
"The gift which I am sending you is called a dog, and is in fact the most precious and valuable possession of mankind" -Theodorus Gaza
Baby Jesus cries when the fat redneck doesn't have military-grade firepower.