My wife thinks it is a little strange. She keeps her Sig P229 on the nightstand with the loaded magazine out of it and lying next to it.
Everyone is different. I personally will not leave a loaded gun out on my nightstand at night. I have a tendency to get up and move around when I am not exactly coherent (get water, stretch legs a little), and I don't want to be able to access a firearm unless I have full knowledge and control of my actions. That is why I like my gunvault. I don't think I would ever have a problem without it, but I really don't want to test that theory... Better safe than sorry, IMO.