As I developed shooting, I went from 22LR to 38spl to 357 mag to 41 mag to 44 mag AND then back to 41 mag. It does everything I want a caliber of this general size does and I shot it better than a 44 mag. That's all I need to know. These were factory loads versus handloads.
Ammunition availabilty is sometimes an issue. But if you do a little planning you can always have 41 mags availabe to you. You just can't walk into Walmart and expect to find any.
I am still hoping that PMC starts loading them again.