I only use .357 cases and load everything from 4.0 grains of Unique up to 6.0 grs. I've pretty much settled on a 5.5gr load as my general-purpose load. I shoot a Missouri Bullet Co 158gr SWC in a 3" Ruger SP101.
"No experience is so conductive for steady and accurate shooting as the knowledge of the impossibility to escape by speed."
-Sir Samuel Baker