Recoil was mentioned as a possible issue. I agree.
I'm not very big but have shot tens of thousands of rounds from my Redhawk .44 maggie. I handloaded all but about 50 of them.
The 245 gr. bullets at max. charges were no problem for me to handle.
But, using 300 gr. bullets at max-max (carefully tested) charges was very uncomfortable and tiring. I would rather place properly and be able to follow-up just as accurately with a 245 that I know will do the job well.