One person above mention to use the heaviest solid bullet. I don't think that would be good, since the bullet would just go through the target.
I personally would question that hypothesis. A bullet as light as the 22 is going to expend its energy very quickly inside a human body. Especially if it hits bone.
And there are plenty of other larger caliber handguns with small grips. Smith and Wesson specifically targets ladies with some of their revolvers.
"I say, boy, I say, you're doing a lot of choppin', but no chips are flyin'."