What are you planning on "stopping"?
For self defense, the Hornaday and exact placement a number of times might "stop" unwanted lethal force being directed your way... then again, as most handguns power levels are a compromise due to the size, it might not "stop" someone soon enough to keep them from doing you some serious bodily harm if you only have 6 shots available.
But I assume you know that.
Try them all out and see what works best for you.
No one in their right mind wants to be shot with anything, let alone a .22 magnum. It's the nefarious ones NOT in their right mind you need worry about. So practice precise placement using whatever round floats your boat and apparently nowadays, you find available.
How you liking that LCR?
A free people ought not only to be armed and disciplined, but they should have sufficient arms and ammunition to maintain a status of independence from any who might attempt to abuse them, which would include their own government." - George Washington, January 8, 1790, First State of the Union Address