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As others have said, there are alternative choices that are likely to be superior in a SD situation. If there are significant reasons why you would prefer a .22, you should bear in mind that the NYPD has constructed a database of all police-perp shootings over the last 30 years or so. When they looked at factors statistically associated with ending the shooting, caliber was not one of them; shot placement was the most important factor. So if you believe you can hit what you aim at with a .22 but are unsure whether that would be the case with a larger caliber, that might be a best choice for you. To reduce the chance of a misfire with a rimfire cartridge, go with specialized target ammo that is highly reliable.
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