I have a S&W 629-6 w/4" barrel. Comfort is secondary to protection, more fire power! If you have access to a Ruger carry a Ruger. If you can shoot a S&W better than an other carry the S&W. Try them all, and pick the 44 mag or bigger that suits you the best!
One other thing, buy some bullets (300 grain). Don't waste money on hollow points or light bullets. I said that like I really know what I'm talking about, that was fun!
Never beat your head against the wall with out a helmet