If GRyder is still reading let's add to his confusion (excuse me 'his enlightenment') by telling him that many traditional revolver rounds, .44 magnum, .357 magnum and .38 special have semi-auto pistols that fire the rounds - Desert Eagle, Coonan, S&W 52.
I love my Coonan. The Desert Eagle is sweet too but its a really big gun.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple