I've used a Blackhawk 357 during one season. 20 yard shot on a big doe. Bullet was a factory 158gr jhp Winchester Ranger or something along those lines. Hit her broadside behind shoulder and she ran off. Couldn't find her with hours of searching. A week later my friend found her about 100 yards away in some heavy brush. Told me it was a perfectly placed shot but hit a rib on way in and didn't see any exit wound.
I hated not finding her but I learned a lesson that day that no doubt a 357 will work but I won't hunt with a jhp handgun round again. That and I upgraded to a 44 mag to better ensure a through and through and higher energy transfer.