There are lots of variables, but guessing can work pretty well.
For best accuracy, I pick:
A flat base match type bullet which is light for the twist rate.
Cases of one make which have been fired out of this rifle. I FL size to bump the shoulder back about .001". I could probably do slightly better with a shoulder bump and bushing neck die.
A powder like Benchmark, Varget, or other which is known to have good accuracy and fills my case to a compressed charge or almost compressed charge.
Primers of one type bought by the 1000 or more so I have 1 lot to develop with. I do buy match primers when I expect to shoot under 1" at 100 yards.
That is how I guess components. I may have really accurate guns, or that is a pretty good method. If your loads are way off, change the bullet.
Basically, I start with lands - 0.030". Then I find a best powder charge for accuracy. At that charge, I will adjust from +0.010 to -0.060 in 0.010" increments. When going long, it might be advisable to back off the powder charge slightly and increase slightly, but this changes 2 variables at once, so I never do that. Then after finding an OAL, I retune the powder charges.
All this said, I tune to a goal, not to "best". Best costs exponentially more than my good enough goal.
Goals like: (5 shot@100 yds)
.5"-.75" for my 300 WSM
2" for my AR
1.5" for 375 JDJ pistol