On larger eastern yotes, I like my .243 Win because it shoots almost as flat as my .270 Win, but shorter and lighter. I've shot them at ranges from 40 yards to 250 and the 6mm is a killing machine, using mostly 75-90 grain bullets.
People are like rifles. Some are tried and true, having great eyes, personality, and fun to be with. Others never seem to hit the mark with you. Still others go off half-cocked. Still, it's nice to know most of them.