Just be ready for some high impacts at 25 yards, unless your sights will crank down really low...
I shoot light loads in my Blackhawks (44 mags) and until you get the speed up there pretty good, you'll have issues getting the sights to set where you want them.
The muzzle flip will be well under-way before the bullet exits, leading to high impacts...
Practical Long Range Rifle Courses...
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