Some people say not to shoot them, or do not shoot them much. They are not as "durable" as later guns. And, as far as that goes, they are right.
BUT, They are fully fine working guns, just not originally designed with a huger number of heavy loads in mind. If you want a gun to shoot the heaviest loads practical, in multiple case lots without needing tuning, the 29, even in its latest beefed up versions isn't the king of the hill.
On the other hand, if you aren't contemplating putting thousands of red line loads a year for decades, the 29 is a fine revolver. Fit, balance, sights, and the legendary trigger pull are all top shelf.
I have a 29-2, inherited from my Father a decade ago. Most of what I shoot is either a lead SWC at around 1100fps or a jacketed 240gr around 12-1300 and change. For heavier loads, I go to other guns, not so much from worry about the 29, but different grip shapes (SA, auto) are more pleasant (or less uncomfortable) to shoot the really hard kickers.
All else being equal (and it almost never is) bigger bullets tend to work better.