While it's possible to size the front third or so of a .22-.250 fired case neck with a full length sizing die, any more sizing typically starts moving the case shoulder forward. The die starts sizing the case body down and that makes its shoulder move forward a bit. That increases case headspace and the bolt will start binding when closed on such a case. The end result is decreased accuracy because the bolt won't lock up in the same place for each round when its chambered. It all depends on the difference between fired case body and sizing die body diameters.
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