My Buckmark has performed admirably for the past 25 years. Can't imagine the round count for that thing. It has seen many, many bricks and bulk packs. I'd often get a brick in Friday after work and have to run to town for another on Saturday so I could shoot Sunday.
Whatever fits your hand best between the Ruger Marks, 22/45 or a Buckmark, pick the one that fits your hand the best and you won't go wrong. These are proven designs that have evolved and passed the test of time. Although pricey the S&W M41 is a good pistol too.
"Courage is being scared to death and saddling up anyway." - John Wayne
.44 Special: For those who get it, no explanation is necessary. For those who don't, no explanation is possible.