A different angle:
The 4" GP100 is probably the best all around handgun manufactured(686 is right in there too). You can do almost anything with it. Some stated you need to go to 6" to hunt and it isn't suitable for polar bear or Grizzly, but you could probably get away with almost anything else.
It wouldn't be my choice if I had ten semi-auto handguns that I shot a lot. I would get a revolver in 45 ACP or maybe 9mm depending on which round I preferred. The 45 ACP revolvers have a decent reputation and the round will also accomplish almost everything I might do.
The other possibility would be a Ruger single six if I just wanted to have a revolver to have one and wasn't planning to use it for anything besides having fun at the range.