Yeah, I've been washing the cylinder (well, the whole gun for that matter) in my garage utility sink with hot soapy water, and I've used a bore brush and patches to go down the bores. But nothing wipes directly against the bottom of the bore. Q-tip is a good idea, but what I really want to find is a tiny bristle brush and bend it into a U shape so I have bristles that can bear against the bottom of the bore. Maybe a .22 bristle brush will do.
I don't take my nipples out after every shoot.