I have large hands, and a Kahr CW45 feels very comfortable to me. It's very compact, but has a longer grip, and a grip that is single-stack thin, but just large enough that the trigger pull is comfortable.
I seriously suggest you consider this gun.
I also read that the CM45 is coming out now. Not sure how that one compares in size, but I loved the CW45. Didn't need another .45 at the time, or I would have bought it.
Last edited by baccusboy; January 29, 2013 at 12:33 PM.