I love carrying my full-size PX4 in a Crossbreed Supertuck Deluxe at 4 o'clock. Super stable and I can hide it under a t-shirt.
Recently I bought an LCR, which is small enough for 1 or 2 o'clock carry, so I'm trying that out. It offers some advantages over 4 o'clock, like being easier to draw while seated, but is not nearly as stable of a ride as the SuperTuck. The Supertuck is more comfortable as well.