If you shoot handguns ok as a lefty, but have trouble with the controls, you might try practicing what the right handed action pistol competitors do, when shooting lefty.
They draw and put the gun into firing mode right handed, and then pass it to the left.
When finished firing, then pass the gun back to the right hand and reholster.
Reloads can done left handed, using the trigger finger for the mag release.
An ambi-dextreous safety will allow you to use either hand for the safety.
For problems, like clearing jams, they usually pass the gun back to the right hand.
Watch some videos of this and see how fast it can be done.
For your wife's vision problem, has she tried a dot scope?
Lock the doors, they're coming in the windows.