Just depends on my mood. If I'm fishing in my pond, I'll usually carry a Single-Six with rat shot. I don't like killing snakes but some are too aggressive for my liking. If I'm out of sight of the house, I'm carrying something bigger than a .22. I've found the remains of a meth lab on my property and I would hate to walk up on somebody who's up to no good and me only have a .22 revolver.
To a much greater extent than most mechanical devices, firearms are terribly unforgiving of any overconfidence, complacency or negligence.