As for .22 ammo, I use bulk almost exclusively. Might get one or two duds in a box of 550.
I used to carry a Ruger SA but I am a bit anti-semi auto for hunting situations. It is a safety issue with me. Having that next round ready to go has a potential for trouble if one is excited or forgetful.
So, I carry my Ruger Single Six with regular lr ammo most of the time. When I had my farm it often had the mag. cylinder in it with the first two rounds up shot capsules for snakes.