I am going to give two powders that I use for .41 Mag. Both work great, and shoot cleanly at reduced loads, and at high pressure. More than I can say for 2400, and Unique. I have used 2400 once. Never again.
AA#9 is great for higher velocity loads with cast lead, or jacketed bullets. It is my go to. I have used H-110 it meters well though I do not gas check my cast so it is not able to be used for cast. It has quite a bit of flash as well. IMR 4227 it works ok. 2400 was dity at low pressure, and with cast bullets.
For light shooting loads Trail Boss will do it well. Great case fill, low recoil, and it is the cleanest burning powder you will ever use.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.