"The .22HE is too delicate overall to withstand repeated firing, particularly double-action."
Not to mention that the revolver was developed originally for blackpowder .22 LONG (not Long Rifle) cartridges, and modern .22 ammunition, especially the high velocity ammo, can split the cylinder.
But... given that an OK example of a LadySmith can easily push into four figures, and a fine example, especially with the box, can approach five figures, I really doubt that too many people are going to be buying these for shooters.
"The gift which I am sending you is called a dog, and is in fact the most precious and valuable possession of mankind" -Theodorus Gaza
Baby Jesus cries when the fat redneck doesn't have military-grade firepower.