There are lots of options. If you want to go really big then the 460 or the 500 magnum. If it was me I would go 357mag or 44mag or a Ruger in 45LC able to take the hot +p loads.
Unless you are in Alaska or the Rocky Mountains (grizzly areas) then a 357 magnum or a 10mm would probably be a good choice. The 41 mag if you reload is a good choice as well.
I like to carry a pistol and a carbine in the same round. For me its 357 magnum but there are more powerful options out there.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...