Personally, given the circumstances and times, I would be looking at 9mm's for semi-autos and .357's for revolvers (capable of shooting .38 special for practice). If you are going to buy a revolver, my preference would be Smith and Wesson. For a semi-auto, there are way too many good 9mm's out there, and that would be a separate topic for discussion if you decided to go that rout.
Buy the .22 later, unless you really want a .22. A .22 handgun is not good for self defense or home defense. Not only does the .22LR round in a handgun have the obvious stopping-power deficiency, but they the rimfire cartridge is ess reliable than center-fire cartridges.