110 grain Hornady over 22.5 grains of H110.
Middle level load from the Hodgdon reloading manual. (still pretty hot)
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...