Thanks for the feedback, the .22WMR looks to be out of the running for my wife for now at least. I'm going to work up some .38 158 gr LSWC loaded with Bullseye to 700-750 fps. I have not played with minimal loads before but apparently heavy bullets with light charges of fast powder is the way to go for reduced recoil and last.
"The ultimate authority ... resides in the people alone. ... The advantage of being armed, which the Americans possess over the people of almost every other nation ... forms a barrier against the enterprises of ambition."
- James Madison