Originally Posted by BigJimP
...I have about 50 handguns...
OMG! A hoarder!
Don't you know those things are dangerous? Send some to me and I'll keep them safe for you.
Back to the OP's point, while a lot of folks disparage .22LR, it does have a very meaningful place. Otherwise it would have faded long ago.
Now, for a primary carry gun, there may - or may not depending on circumstances, be a better choice. You have to figure that out for yourself based on your circumstances. I'd take a .22 over a .25 any day of the week.
My wife has a .380, which a lot of people also think is too wimpy. But it beats the pants off begging for mercy.
9mm has the lions share of the market because it has a lot of advantages most people desire. But, as I said, if .22 was completely useless it would have faded long ago.