The only gun/cartridge combo that I have found unpleasant enough to avoid is the 500 S&W shooting 600 -700 grain bullets from my T/C Encore pistol.
I assembled that combo in order to test handloads.
Shooting it hurt from shot one.
I have heavy rifles - a .416 Rigby, a .375 H&H, a Handi-Rifle for hot .45-70s. A box or so of cartridges from each is normal.....but not that 500 Encore pistol.
“Auto racing, bull fighting, and mountain climbing are the only real sports ... all others are games.” Ernest Hemingway ...
NRA Life Member