Again some reading is in order as not to repeat :
Gunblast New Vaquero
Gunblast New Vaquero Revisited
Brian Pearce PDF on loads for the mediam frame New Vaquero :
Brian Pearce .45 Colt PDF
Should give you some good ideas on what you have and some loads.
I've used a lot of different combinations of powder and bullets. My current goto load is 7.0g of Green Dot under 250g RNFP. My heavier load is 13g of HS-6 under 255g SWC.
A clinger. When guns are outlawed, only outlaws will have guns. Single Action .45 Colt (Sometimes improperly referred to by its alias as the .45 'Long' Colt or .45LC). Don't leave home without it. Ok.... the .44Spec is growing on me ... but the .45 Colt is still king.