Different guns (barrels) shoot different bullets differently. A given gun may not shoot as accurately with the same load in another gun. What degree of accuracy are you looking for?
For the absolute best accuracy you will want to slug your barrel and use a bullet matched to the groove diameter. Once you have that, you will need to experiment with different powders and charge weights to find the sweet spot for that particular gun.
With my 30-06 for example I size the brass then I process each case in a LEE target die set which removes all of the variables to the case neck, I then sort the brass into lots by weight, headstamp etc. I measure and weigh each powder charge and use an RCBS competition die to seat the bullet. Doing this results in loads capable of sub MOA in my rifle.
My rifle and pistol are tools, I am the weapon.