Its a pretty subjective question. More than any caliber I would recommend getting a bolt action so you can neck size your brass to get much more life out of it and do hardly any triming and annealing. Thats just my advice though. Killing dear is more about shooting them in the right spot than the specific cartridge you use to do it. When in doubt stick with something popular like a 243, 308, 270 or 30-06.
New gun, same ol' shot.
Last edited by Adamantium; January 16, 2013 at 03:02 AM.