I had a hard time loading the magazine at the correct angle, figuring out when the magazine was completely seated and sometimes I had a hard time getting the bullets to load into the chamber.
Having the cartridges not properly chamber might be related to the magazine not being fully seated. This seems to be a weak point with the 22/45, but is easily corrected.
You just need a thicker base plate that isn't flush with the bottom of the frame. You can purchase replacements, these for example: http://www.tech-custom.com/
, or you can fashion your own from rubber or other material and contact cement them to the bottom of the stock base pads. Be sure to leave a hole in the bottom to access the plunger to disassemble the magazine.