In my limited experience, yes. At 2840 FPS muzzle velocity I've put .264 130 grain hunting VLD's out of my 260 through:
A hogs spine(neck shot), shattered the spine with chunks of vaporized vertebrae on the ground behind him, and still entered his sister behind him's skull, killing her instantly as well with no exit. This shot was at about 65 yards. Not sure how much bullet was left after going clean theough the first one's vertebrae, but it was enough.
A doe's spine at 15 yards, blew right on through and what was left lodged in the tree behind her.
A buck's shoulder from 250 yards. Huge ghastly exit wound on the other side, but broke through the onside shoulder and broke through a rib on the other side exiting.