I should add to my post above about the blackhawk - the weight really helps with recoil absorption, which seems to help with accuracy. I would say 50 yards is within a good handgun hunting range with it, maybe more depending on how cold I am.
I just pulled mine out since I was thinking about it, figured I would clean it a little. Man, it is a nice looking single action.
I think the USFA or a Freedom Arms model 97 would be quite excellent for this round.
.327 SP101, .327 Blackhawk, .45 Vaquero, Browning Maxus, Browning Silver Lightning, Ruger no.1 .243, Stoeger .410 sxs, TC Contender, Remington 870 Wingmaster, Uberti 1860, Hawken, Moisin, Mauser, Marlin 60