I should add to my post above about the blackhawk - the weight really helps with recoil absorption, which seems to help with accuracy. I would say 50 yards is within a good handgun hunting range with it, maybe more depending on how cold I am.
I just pulled mine out since I was thinking about it, figured I would clean it a little. Man, it is a nice looking single action.
I think the USFA or a Freedom Arms model 97 would be quite excellent for this round.
.327 SP101 3", .327 Blackhawk, S&W 686+ 5", S&W 686+ 3", S&W 581 4", Ruger no.1 .243, Ruger no. 1 .280, TC Contender, Stoeger .410 SxS, some sort of SKS