I did a lot of experimentation with H110/296 in my 4" S&W model 28, and it does produce great velocity. My problem with it is that in the 4" barrel it makes for a really sharp, obnoxious muzzle blast.
I ended up going back to 2400. I can get so close to the same velocity that the difference is irrelevant. While I tend to favor the newer powders, 2400 is one that I just keep coming back to.