I have a TC Encore that does what you are asking. I also have a Remington 870 that I have 2 barrels for.
I have seen Walther P22s and Ruger 22 mk pistols with different barrels.
If you are willing to lay down the money yo could have a good smith custom build you a barrel.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...