How to define difficult relative to pretty much everything else? Number of steps? Tools recommended by the manual? Tools actually needed? Likelihood of scratching something? Maybe telekinetic powers to manipulate internal parts as you reassemble it, which is even harder than takedown. Cleaning difficulty? Holy nooks, crannies, and angles!
I won't deny Ruger Marks are THE king of affordable 22 quality. I owned a Mk3 long, stainless fluted (Target Hunter I think it was). Extremely accurate and reliable. But honestly I just didn't have the patience since I fully clean after every shoot.
Shoot smart. Shoot S-Mart.