FWIW; a ex-cop I worked with in 2005 during a storm recovery detail(Wilma), told our security group about a large male(6'06") who was shot by his wife in a domestic dispute. She only fired 1 round of .22short to the center of the chest. The ex-cop said the guy fell over dead.
Two words, shot placement
NRA Life Member, NRA Range Safety Officer, NRA Certified Pistol Instructor, IDPA Safety Officer, USPSA NROI Range Officer,
As you are, I once was, As I am, You will be.