FWIW; a ex-cop I worked with in 2005 during a storm recovery detail(Wilma), told our security group about a large male(6'06") who was shot by his wife in a domestic dispute. She only fired 1 round of .22short to the center of the chest. The ex-cop said the guy fell over dead.
Two words, shot placement
NRA Life Member, NRA Range Safety Officer, IDPA Safety Officer, USPSA NROI Range Officer
As you are, I once was, As I am, You will be.